1Cor. 3:16 "Do you not know that you are the temple of God and that the Spirit of God dwells in you?" This, among other similar passages, teach us that the Spirit of God becomes a part of our lives in a unique and living way through salvation in Jesus Christ. Because the Holy Spirit is not of flesh, there is no way to sense His presence in us. It is through faith we know He is there.
By faith we can understand that the Holy Spirit dwelling in us is a great advantage. This gift from the Father makes the difference between carrying the cross to the glory of God, and just being self-willed. “That good thing which was committed to you, keep by the Holy Spirit who dwells in us.” (II Tim.1:14) Timothy had a job to do. He was given the gift to be an evangelist through the church (the laying on of hands by the presbytery). He was given some ability by the Holy Spirit through Paul’s laying on of hands. But none of these gifts would have been used without Timothy having the gift of the Spirit through conversion. This is what enabled him to “keep” what was committed to him.
This help from above is what enables all disciples to carry out their responsibilities even in the face of great distress. It is the edge of being alive in Christ “. . . who through the eternal Spirit offered Himself without spot to God. . .” (Heb.9:14)